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Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

Series
To Immunity and Beyond
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Professor Astrid Iversen discusses research published in Nature, using historic genome data to investigate the emergence of genetic risk for multiple sclerosis in Northern Europe.
This episode discusses Barrie, W, Yang, Y, Irving-Pease, EK, et al. Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations. Nature 625, 321–328 (2024). https://doi.org/10.1038/s41586-023-06618-z

Article funding and acknowledgments: https://www.nature.com/articles/s41586-023-06618-z#Ack1

This study was international and multidisciplinary in nature, and Professor Iversen is grateful for the vital work done by Professor Willerslev, his group, and their collaborators. Professor Iversen also gratefully acknowledges the critical contributions of the shared first authors – William Barrie, Yaoling Yang, Evan K. Irving-Pease, Kathrine E. Attfield, Gabriele Scorrano, and Lise Torp Jensen – as well as those of fellow shared last authors: Daniel J. Lawson, Lars Fugger, and Eske Willerslev.

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To Immunity and Beyond

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Professor Quentin Sattentau discusses research published in 'Nature Communications' on the role of enzyme ADAM10 in mediating clearance of apoptotic T cells by macrophages.
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Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/
Transcript Available

Episode Information

Series
To Immunity and Beyond
People
Astrid Iversen
Paul Klenerman
Keywords
MS
pastoralist
Yamnaya
genomics
Pontic-Caspian steppe
migration
Multiple sclerosis
Department: Oxford Immunology Network
Date Added: 06/11/2024
Duration: 00:04:22

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